First thing you would need to ensure that , Region always work on co-ordinates or image basis . If you would go with co-ordinate then it would not work because every time region position will change now you would go with image properties and also check fonts of image are fixed or not and colour and background colour are fixed . You can use read text with OCR and you would receive text on that and for click on region you would use global mouse click or global mouse click center in region the. Radio button will checked
Kindly met me know in case you want more help.